Thermodynamics allows the formation of abiotic (prebiotical) molecules directly into the depths of earth and during underwater and terrestrial eruptions. The formation of HCN and other abiogenous molecules observed in electrical discharges, especially during the eruption of volcanoes. It was found that the synthesis of adenine and many other primary prebiotic molecules on a young and modern earth is beneficial from the standpoint of thermodynamics. As a result of actions of the structural stabilization and the principle of substance stability the purine and pyrimidine nucleobases can exist during relatively long time and be involved to the metabolism of living organisms. Some complex supramolecular structures – harbingers of life appear and in our time. However, these structures can be eaten by modern organisms, which prevent the formation of new forms of life.